Efficacy of modified electroconvulsive therapy in different wave widths and its impact on cognitive function in treating patients with major depression
Objective To observe the efficacy of modified electroconvulsive therapy(MECT)with different wave widths and its impact on cognitive function in the treatment of the patients with major depression.Methods A total of 100 hospitalized patients with major depression were randomly divided into two groups with 50 cases each.During MECT,the wave width was set to 1.0 ms in group A and that was set to 0.5 ms in group B.The 17-item Hamilton depression scale(HAMD-17)score,association and recognition scores of Wechsler memory scale,and serum levels of 5-hydroxytryptamin(5-HT)and brain-derived neurotrophic factor(BDNF)were compared between the two groups before and after MECT treatment.The incidences of adverse reactions were oberserved.Results After MECT for one and two weeks,the reduction rate of HAMD-17 scores in group B was higher than that in group A(P＜0.05).After treated for two weeks,both the association and recognition scores in group B were higher than those in group A(P＜0.05).Additionally,serum 5-HT and BDNF levels in group B were higher than those in group A after MECT for two weeks(P＜0.05).There were no statistically significant differences between the two groups in the incidences of dizziness,headache,nausea and gastric discomfort(P＞0.05).However,the incidence of arrhythmia in group B was higher than that in group A(P＜0.05).Conclusion In the treatment of the patients with major depression,MECT with a wave width of 0.5 ms has better efficacy in the improvement of cognitive function,but with a prone to produce arrhythmia.
Modified electroconvulsive therapyMajor depressionCognitive function
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维普
