Clinical outcome of modified electroconvulsive therapy on major depression under different pulse width stimulation and its impact on peripheral blood circular RNA expression
Objective To explore the clinical outcome of modified electroconvulsive therapy under different pulse width stimulation in the patients with major depression and its impact on peripheral blood circular RNA(circRNA)expression.Methods Eighty-six patients with major depression were randomly divided into two groups with 43 cases each.Group A and group B accepted modified electroconvulsive therapy under pulse width stimulation of 4 ms+1 ms+4 ms and 2 ms+1 ms+2 ms,respectively.A total of 6 treatments were administered.Hamilton depression scale-17(HAMD-17)score and reduction rate,mini-mental state examination(MMSE)score,activity of daily living scale(ADL)score,peripheral blood circRNA expression and total clinical effective rate were compared between the two groups.Results Compared to before treatment,the total and subdomain MMSE scores and ADL score were higher after treatment in both groups,which in group B were higher than those in group A(P＜0.05).After 3 treatments,the HAMD-17 score reduction rate in group B was higher than that in group A(P＜0.05).After treatment,the expressions of hsa_circRNA_103102 and hsa_circRNA_103704 in peripheral blood were higher,while the expression of hsa_circRNA_104597 was lower,in group B than those in group A(P＜0.05).The total clinical effective rate in group B was higher than that in group A(P＜0.05).Conclusion Under 2 ms+1 ms+2 ms pulse width stimulation,modified electroconvulsive therapy can increase the expressions of hsa_circRNA_103102 and hsa_circRNA_103704,decrease the expression of hsa_circRNA_104597 in the patients with major depression,and achieve better clinical outcome.
Major depressionModified electroconvulsive therapyPulse widthCircular ribonucleic acid
万方数据
维普
