Protective effect of preoperative aerosol inhalation of penehyclidine hydrochloride on lung injury in patients undergoing cardiac valve replacement under cardiopulmonary bypass
Objective To observe the protective effect of preoperative aerosol inhalation of penehyclidine hydrochloride(PHC)on the lung injury in the patients undergoing cardiac valve replacement under cardiopulmonary bypass(CPB).Methods Ninety patients undergoing cardiac valve replacement under CPB were randomly divided into three groups with 30 cases each.At 30 minutes before anesthesia induction,group A was given PHC 0.5 mg aerosol inhalation,group B was given PHC 0.5 mg intravenous injection,and group C was given equal volume normal saline intravenous injection.Respiratory index(RI),oxygenation index(OI)and serum inflammatory factors were measured before CPB(T0),30 minutes after CPB(T1),the end of operation(T2)and 24 hours after operation(T3).Results At T0,there were no significant differences in RI,OI and serum levels of IL-8 and TNF-α among the three groups(P＞0.05).From T1 to T3,RI and serum levels of IL-8 and TNF-α in group A were lower than those in groups of B and C(P＜0.05).OI in group A was higher than that in groups of B and C at T1 and T2(P＜0.05),and higher than that in group C at T3(P＜0.05).Conclusion Compared with intravenous administration,preoperative aerosol inhalation of PHC has a better protective effect on the lung injury in the patients undergoing cardiac valve replacement under CPB,which can effectively improve oxygenation and lung function,and relieve inflammatory response.
万方数据
维普
