Application of two-stage 4％sodium citrate anticoagulation in hemodialysis patients with high-risk bleeding tendency
Objective To observe the effect of two-stage 4％sodium citrate anticoagulation in hemodialysis patients with high-risk bleeding tendency.Methods A total of 100 hemodialysis patients with high-risk bleeding tendency were randomly divided into two groups with 50 cases each.During hemodialysis treatment,group A was treated with two-stage 4％sodium citrate anticoagulation and group B was treated with low molecular weight heparin anticoagulation.The blood coagulation of dialyzer and venous pot was observed.The thrombin time(TT),activated partial thromboplastin time(APTT),prothrombin time(PT),fibrinogen(Fib),Ca2+,Na+,K+,P3+,carbon dioxide combining power(CO2CP),single ventricular urea clearance index(spKt/V)and urea decline rate(URR)before and after hemodialysis and treatment completion time were compared between the two groups.The adverse responses were recorded during treatment.Results There were no significant differences in TT,APTT,PT and Fib before and after hemodialysis in group A(P＞0.05),while TT,APTT and PT after hemodialysis in group B were longer than those before hemodialysis(P＜0.05).There was no significant difference in the proportion of blood clotting of dialyzer and venous pot between the two groups(P＞0.05).There were no significant differences in Ca2+,Na+,K+,P3+,CO2CP,spKt/V,URR after hemodialysis,and treatment completion time between the two groups(P＞0.05).The incidence of adverse responses was similar between the two groups(P＞0.05).Conclusion In hemodialysis patients with high-risk bleeding tendency,two-stage 4％sodium citrate anticoagulation is safe and effective.
万方数据
维普
