Relationship between serum SAA,HBP levels and NAP score and secondary pulmonary infection and prognosis in patients with severe craniocerebral injury
Objective To investigate the relationship between serum amyloid A(SAA),heparin-binding protein(HBP)levels and neutrophil alkaline phosphatase(NAP)score and the development of secondary pulmonary infection and prognosis in the patients with severe craniocerebral injury.Methods A total of 100 patients with secondary pulmonary infection after severe craniocerebral injury were selected as group A.Another 100 patients with severe craniocerebral injury without pulmonary infection during the same period were selected as group C.The clinical data,SAA and HBP levels and NAP score of the two groups were compared.ROC curve was used to analyze the value of SAA,HBP levels and NAP score in predicting the secondary pulmonary infection of the patients with severe craniocerebral injury.According to the prognosis,the patients in group A were subdivided into group A1(with good prognosis,44 cases)and group A2(with poor prognosis,56 cases).The levels of SAA,HBP and NAP score were compared between groups of A1 and A2.Results The levels of SAA,HBP and NAP score were significantly higher in group A than those in group C(P＜0.05).ROC curve analysis showed that the AUC of combined detection of SAA,HBP levels and NAP score in predicting secondary pulmonary infection of the patients with severe craniocerebral injury was 0.991[95％CI(0.972～0.998),P＜0.05].The levels of SAA and HBP and NAP score in group A1 were lower than those in group A2(P＜0.05).Conclusion The levels of SAA and HBP and NAP score are higher in the patients with severe craniocerebral injury complicated with secondary pulmonary infection,which are much higher in the patients with poor prognosis.Combined detection of SAA,HBP levels and NAP score in predicting the pulmonary infection secondary to severe craniocerebral injury has clinical significance.
万方数据
维普
