Efficacy of dienogest combined with leuprorelin in the treatment of patients with endometriosis
Objective To investigate the efficacy of dienogest combined with leuprorelin in the treatment of the patients with endometriosis.Methods Eighty patients with endometriosis were randomly divided into two groups with 40 cases each.After laparoscopic surgery treatment,group B was treated with dienogest,and group A was treated with dienogest combined with leuprorelin.The VAS pain score,clinical efficacy,ovarian reserve function,menstrual volume,adverse reactions,mass volume and CA125 level were compared between the two groups.Results After treated for 3 months,non-menstrual abdominal pain score,dysmenorrhea score and levels of estradiol,follicle stimulating hormone and CA125 were lower,anti-Müllerian hormone level,antral follicle counting and menstrual volume score were higher,and mass volume was smaller than those before,which were improved more obviously in group A than those in group B(P＜0.05).The total effectiveness rate of group A was higher than that of group B(95.00％vs.77.50％)(P＜0.05).The incidence of adverse reactions was lower in group A than that in group B(5.00％vs.30.00％)(P＜0.05).Conclusion Dienogest combined with leuprorelin has better efficacy in the treatment of the patients with endometriosis,which can relieve pain,restore ovarian reserve function,improve menstrual disorders,and has fewer adverse reactions.
EndometriosisDienogestLeuprorelinOvarian reserve function
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