Efficacy of anesthesia induction with different doses of propofol in elderly depression patients undergoing modified electroconvulsive therapy
Objective To explore the efficacy of anesthesia induction with different doses of propofol in elderly depression patients undergoing modified electroconvulsive therapy(MECT).Methods A total of 93 elderly depression patients undergoing MECT were randomly divided into three groups with 31 cases each.During anesthesia induction,propofol 1.0 mg/kg was injected in group A,1.2 mg/kg was injected in group B and 1.5 mg/kg was injected in group C.The administration time was not less than 30 seconds.When the Narcotrend(NT)index was less than 60,succinylcholine 1.0 mg/kg was injected intravenously.MECT was performed after complete muscle ralaxation.MAP and HR were recorded before anesthesia(T0),immediately before MECT(T1),1 minute(T2)and 10 minutes(T3)after MECT.The NT index at T1,convulsion time,respiratory recovery time and awakening time were recorded.The myocardial enzyme profiles were detected 30 minutes before MECT and 24 hours after MECT.The occurrence of adverse reactions during the recovery period was recorded.Results Compared with T0,MAP was decreased at T1 and increased at T2,and HR was increased at T1 and T2 in three groups(P＜0.05).MAP was lower in group C than that in groups of A and B at T1,which was lower in groups of B and C than that in group A at T2(P＜0.05).HR was lower in groups of B and C than that in group A at T1 and T2(P＜0.05).Compared with group A,the NT index was decreased and the convulsion time was shortened in groups of B and C(P＜0.05).The awakening time was shorter in groups of A and B than that in group C(P＜0.05).Compared with group A,the incidences of coughing,agitation and delirium were lower in groups of B and C during recovery period(P＜0.05).Conclusion Compared to anesthesia induction with propofol 1.0 or 1.5 mg/kg,anesthesia induction with propofol 1.2 mg/kg has the advantages of more stable circulation,faster recovery and lower incidence of adverse reactions in elderly depression patients undergoing MECT.
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