CMC-MMA-AA纳米乳液的制备及其抗蛋白质吸附性能的研究
Study on Preparation of CMC-MMA-AA Nanoemulsion and Its Anti-protein Adsorption Properties
罗欣昕 1王甦晓1
作者信息
- 1. 湖北大学化学化工学院,武汉 430062
- 折叠
摘要
本文以羧甲基纤维素(CMC)为乳化剂,甲基丙烯酸甲酯(MMA)和丙烯酸(AA)为单体,H2O2+Fe2+为引发剂,采用乳液聚合技术制备了 CMC-MMA-AA纳米乳液.通过SEM、DLS、TG、IR对乳胶粒的理化性质进行表征,并采用BLI、SDS-PAGE等方法验证纳米粒子的抗蛋白质吸附性能.结果表明:使用羧甲基纤维素包被后的聚甲基丙烯酸甲酯-丙烯酸纳米粒子粒径大小均一,粒径分布较窄,且具备良好的抗蛋白质吸附性能.
Abstract
In this study,a nanoemulsion(CMC-MMA-AA)was prepared using emulsion polymerization technology,employing carboxymethyl cellulose(CMC)as the emulsifier,and methyl methacrylate(MMA)and acrylic acid(AA)as monomers,with H2O2+Fe2+serving as initiators.The physicochemical properties of the latex particles were characterized through SEM,DLS,TG,and IR analyses,while the resistance to protein adsorption of the nanoparticles was validated using BLI,SDS-PAGE,and other techniques.The findings revealed that the carboxymethyl cellulose-coated poly(methyl methacrylate-acrylic acid)nanoparticles exhibited uniform particle size,a narrow particle size distribution,and outstanding resistance to protein adsorption.
关键词
甲基丙烯酸甲酯/羧甲基纤维素/乳液聚合/抗蛋白质吸附Key words
Methyl Methacrylate/Carboxymethylcellulose/Emulsion Polymerization/Anti-protein adsorption引用本文复制引用
出版年
2024
NETL
NSTL
万方数据