"三明治"结构银@聚多巴胺@银空心微球的制备及其抗菌性能研究
Preparation and Antibacterial Properties of"Sandwich"Structured Silver@Poly dopamine@Silver Hollow Microspheres
朱鹏程 1尚斌 2邓字巍2
作者信息
- 1. 赣南医科大学第一附属医院,江西赣州 341000
- 2. 陕西师范大学材料科学与工程学院,西安 710119
- 折叠
摘要
本研究采用磺化聚苯乙烯(SPS)微球为模板,利用聚乙烯吡咯烷酮对银氨离子([Ag(NH3)2]+)的稳定和还原特性,在微球表面负载Ag纳米粒子,形成SPS@Ag复合微球.随后,在弱碱性条件下,利用多巴胺仿生修饰在复合微球表面构建了聚多巴胺(PDA)壳层.并借助PDA壳层表面活性基团,进一步将[Ag(NH3)2p原位还原为Ag纳米粒子,并紧密固定在PDA壳层上.通过溶剂选择性溶解SPS微球,最终制备出"三明治"结构银@聚多巴胺@银(Ag@PDA@Ag)空心微球.在抗菌性能评估中,Ag@PDA@Ag空心微球对革兰氏阴性大肠杆菌和革兰氏阳性金黄色葡萄球菌均展现出卓越的抗菌活性和持久的抗菌效果.这一研究不仅为抗菌材料的设计提供了新思路,还为实际应用中对抗多种细菌感染提供了有力的候选材料.
Abstract
In this study,sulfonated polystyrene(SPS)microspheres were employed as templates,leveraging the stabilizing and reducing properties of polyvinylpyrrolidone(PVP)towards silver ammine ions([Ag(NH3)2]+)to deposit Ag nanoparticles on the microsphere surfaces,forming SPS@Ag composite microspheres.Subsequently,under mildly alkaline conditions,a layer of polydopamine(PDA)was bio-inspiredly grafted onto the composite microsphere surfaces through dopamine modification.Utilizing the reactive groups on the PDA shell,[Ag(NH3)2]+ions were in-situ reduced to Ag nanoparticles,which were securely anchored onto the PDA shell.By selectively dissolving the SPS microspheres with a solvent,hollow microspheres with a"sandwich"structure of silver@polydopamine@silver(Ag@PDA@Ag)were ultimately fabricated.In antibacterial performance evaluations,the Ag@PDA@Ag hollow microspheres displayed remarkable antibacterial activity and sustained efficacy against both Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus.This research not only introduces a novel strategy for the design of antimicrobial materials but also offers a potent candidate material for combating a broad spectrum of bacterial infections in practical applications.
关键词
"三明治"结构/空心微球/银纳米粒子/聚多巴胺/抗菌Key words
Sandwich Structure/Hollow Microspheres/Ag Nanoparticles/Polydopamine/Antibacterial引用本文复制引用
基金项目
江西省教育厅科学技术研究一般项目(GJJ211522)
出版年
2024
NETL
NSTL
万方数据