Effects of rRNA secondary structure on topological accuracy: a case study based on fungal 18S rRNAs
Different methods using rRNA secondary structure to assist phylogenetic analyses have been recently developed.In order to evaluate the structure information on accuracy of phylogenetic tree topology,comparisons of these methods were performed.Our results showed significant superiority of phylogenetic analyses incorporating secondary structure over the pure traditional approaches.When the three major factors,alignment method,evolutionary model and tree search algorithm,were considered simultaneously in phylogenetic analyses,the implementation of structure information in alignment and substitution model produced a noticeable positive effect on topological accuracy.
phylogenysequence analysistopological accuracy
刘超洋、庄文颖
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西南科技大学生命科学与技术学院 绵阳621010
中国科学院微生物研究所真菌学国家重点实验室(筹)北京100101
系统发育 序列分析 拓扑结构
Supported by the Talent Grant of Southwest University of Science and Technology to CYL国家自然科学基金Knowledge Innovation Program of the Chinese Academy of Sciences