Synthesis of 5-Bromo-2,3-dihydrobenzofuran-7-sulfonyl Chloride
5-Bromo-2,3-dihydrobenzofuran-7-sulfonyl chloride as a derivative of heterocyclic sulfonyl chloride containing a dihydrobenzofuran skeleton was synthesized from phenol through a four-step reaction including substitution,cyclization,bromination and chlorosulfonation.The synthetic conditions were optimized for the chlorosulfonation step.The optimized conditions were as follows:the molar ratio of n(5-bromo-2,3-dihydrobenzofuran)∶n(chlorosulfonic acid)=1∶6,under the reaction temperature of 25℃,reaction time of 2.5 h.The yield under the optimized conditions reached 81％.The target product was confirmed by 1H NMR,13C NMR,HRMS,and IR.
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