Improvement on the Synthesis of Tandospirone Citrate
Tandospirone citrate was synthesized from 2-chloropyrimidine via a processes including N-hydrocarbylation,quaternization,nucleophilic and salify with a total yield of 65.2％and a chromatographic purity of 99.9％.The affecting factors including the acid-binding regent,the reaction temperature,solvent and the catalyst were investigated.The structures of the product and intermediates were characterized by 1H NMR and ESI-MS.The preparation process was simple in operation,low in raw material cost,and suitable for industrial production.
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