Synthesis of 3-((1-Methyl-1H-pyrrol-2-yl)methylene)indolin-2-one
3-((1-Methyl-1H-pyrrol-2-yl)methylene)indolin-2-one was synthesized from indoline-2-one and N-methyl-2-pyrrole-formaldehyde via Aldol condensation reaction.The structure of the product was characterized by proton NMR(1H NMR)and mass spectrometry(ESI-MS).The optimum conditions of the aldol condensation reaction were as follows:piperidine was used as the organic base catalyst;the molar ratio of materials was n(piperidine)∶n(N-methyl-2-pyrrole-formaldehyde)∶n(indoline-2-one)=0.2∶1.2∶1.0,the reaction solvent was ethanol,the reaction temperature was 80 ℃,and the reaction time was 5 h.A yield of product was up to 73.4％under these reaction conditions.
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