Analysis of Degradable Impurities in Compound Sulfamethoxazole Tablets
By examining products and pathways from the degradation of compound sulfamethoxazole tablets,effective impurity analysis of drugs can be carried out to improve the level of drug quality control.Samples of compound sulfamethoxazole tablets,blank excipients,blank excipients with trimethoprim,and blank excipients with sulfamethoxazole were taken for destruction tests to investigate the degradation of each sample under light,heat,acid,alkali,and oxidation conditions.The main impurities from degradation included sulfamethoxazole oxidation impurities 1 and 2 under oxidative damage conditions,trimethoprim impurity F,and larger sulfamethoxazole impurities C and D under light damage conditions.By studying the impurities from degradation,the risk of impurities from degradation in formulation processes and storage can be effectively avoided.The liquid chromatography conditions in this experiment can also be used to simultaneously monitor the impurities from degradation in compound,and improve quality standards.
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