In order to effectively control the quality of parecoxib sodium and to establish quality standards,2-bromophenylacetone was used as the starting material,condensed with tetrandrine,and then cyclized,stripped of tetrandrine,coupled,oxidized,sulfonated,and condensed with propionic anhydride to obtain the Parecoxib Sodium impurity,N-((2-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)propanamide(9),the structure of which was confirmed by 1H NMR and MS,and the synthetic process was optimized,and purification with an overall yield about 42.8％(as 2-bromophenylacetone)and a purity of 99.0％(HPLC).The structure of impurity were confirmed by 1H NMR and MS.The conditions for synthetic process were optimized.This synthetic process is reasonable and feasible,the reaction conditions are mild,and the impurity purity is high.It can be used as the reference substance for the quality control of parecoxib sodium.
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