Research on FeCl3-catalyzed N-H Alkylation of Pyridazinone Derivatives via the CDC Strategy
A method for the formation of a C-N bond between pyridazinone N-H and alkylic C(sp3)-H through FeCl3 catalyzed cross dehydrogenative coupling was developed under mild reaction conditions.Various pyridazinones could react smoothly with oxy/thioethers to provide the N-oxy/thioalkyl pyridazinone derivatives with moderate to good yields(44% ～83% ).This method provides an alternative tactic to construct potentially bioactive N-substituted pyridazinones.
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