CDC策略下三氯化铁催化哒嗪酮衍生物N-H烷基化研究
Research on FeCl3-catalyzed N-H Alkylation of Pyridazinone Derivatives via the CDC Strategy
赵雯静 1曾钟威 1颜芊 1刘叶 1胡洋 1李志伟 1刘瀚文1
作者信息
- 1. 长沙理工大学化学化工学院,湖南长沙 410114
- 折叠
摘要
利用FeCl3催化的交叉脱氢偶联反应,在温和反应条件下,建立了哒嗪酮N-H与烷基C(sp3)-H之间形成C-N键的方法.不同的哒嗪酮类化合物与氧/硫醚反应,顺利得到了一系列N-氧基/硫烷基哒嗪酮衍生物,收率为44％～83％.该方法为构建具有潜在生物活性的N-取代哒嗪酮类化合物提供了一种新的策略.
Abstract
A method for the formation of a C-N bond between pyridazinone N-H and alkylic C(sp3)-H through FeCl3 catalyzed cross dehydrogenative coupling was developed under mild reaction conditions.Various pyridazinones could react smoothly with oxy/thioethers to provide the N-oxy/thioalkyl pyridazinone derivatives with moderate to good yields(44% ～83% ).This method provides an alternative tactic to construct potentially bioactive N-substituted pyridazinones.
关键词
交叉脱氢偶联反应/N-H烷基化/哒嗪酮/醚/催化Key words
CDC reactions/N-H alkylation/pyridazinones/ethers/catalysis引用本文复制引用
出版年
2024
NETL
NSTL
万方数据