Synthesis and Evaluation of Anti-pancreatic Cancer Activity of Novel 1H-Pyrrolo[2,3-c]pyridine Derivatives
Pancreatic cancer has a high malignancy rate and there are very few therapeutic drugs.It is of great significance to develop compounds with anti-pancreatic cancer activity.By modifying the nitrogen at 1 position of 1H-pyrrolo[2,3-c]pyridine,22 compounds were synthesized.Compounds anti PANC-1 cell's activities were evaluated,Ⅱ-1 exhibited great activity(IC50=3.61 μmol/L).Anti migration and invasion abilities of Ⅱ-1 were studied using wound healing and invasion assay.After being treated with Ⅱ-1 at a concentration rate of 1,5,and 10 µmol/L for 24 h,the migration rates of PANC-1 cells declined 28% ,41% ,and 54% vs the control group,respectively.After being treated with Ⅱ-1 at a concentration rate of 1,5,and 10 μmol/L for 48 h,the migration rates declined 25% ,46% ,and 49% vs the control group,respectively.After being treated with Ⅱ-1 at concentration of 1,5,and 10 µmol/L for 48 h,the relative invasion abilities of PANC-1 cells declined 64% ,79% ,and 89% vs the control group,respectively.These experimental results indicate that Ⅱ-1 has high inhibitory effects on PANC-1 cells,and has prominent ability to inhibit the migration and invasion of PANC-1 cells.
chemical synthesis1H-pyrrolo[2,3-c]pyridineanti pancreatic cancer activity
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