甲磺酸达氟沙星N-脱甲基杂质的合成研究
Synthesis of N-Demethylated Impurities in Danofloxacin Mesylate
单国洋 1黄秋波 1许培德 1曹勇 1凃鑫1
作者信息
- 1. 浙江国邦药业有限公司,浙江上虞 312369
- 折叠
摘要
研究一种制备甲磺酸达氟沙星N-脱甲基杂质标准品的方法.以甲磺酸达氟沙星为起始原料,通过碘氧化实现N-脱甲基反应,随后进行精制和后处理步骤,最终获得含量97.13％(HPLC)的目标杂质标准品N-脱甲基.方法操作简便且产物纯度高,其结构经1H NMR、HRMS等确证.
Abstract
This research is to develop a method for preparing N-demethylated impurity reference standards of Dafloxacin Mesylate.This method uses Danofloxacin Mesylate as the initial raw material,it also utilized iodine-mediated oxidation to carry out the demethylation reaction.Following this,refinement and post-processing steps are conducted to reach a target for impurity reference standards N-demethyl at 97.13% (HPLC).The advantages of this approach lie in its simplicity of operation and the high purity of the product,with the structure confirmed by techniques such as 1H NMR and HRMS.
关键词
达氟沙星/N-脱甲基杂质/合成Key words
Danofloxacin/N-demethylated impurities/synthesis引用本文复制引用
出版年
2024
NETL
NSTL
万方数据