S-美托洛尔及其关键中间体的合成研究进展
Progress in Synthesis of S-metoprolol and Its Key Intermediates
邱飙1
作者信息
- 1. 闽西职业技术学院智能制造学院,福建龙岩 364000
- 折叠
摘要
综述了 S-美托洛尔的化学全合成工艺.S-美托洛尔的合成需要先拆分外消旋环氧氯丙烷,再与关键中间体4-(2-甲氧基乙基)苯酚对接,以苯乙醇、对氯苯酚、苯酚、对羟基苯乙酮、对羟基苯乙酸甲酯、对硝基甲苯等为原料都可以合成4-(2-甲氧基乙基)苯酚.以苯乙醇为原料合成该中间体的工业化案例最多、成本最低,但硝化反应危险性大;产生的副产金属盐导致三废处理压力较大.使用对氯苯酚工艺和苯酚工艺的企业较少.对羟基苯乙酮、对羟基苯乙酸甲酯等工艺目前尚处于研究阶段,也有一定的发展前景.
Abstract
The review describes the chemical total synthesis process of S-metoprolol.The synthesis of S-metoprolol begins with the separation of racemic epichlorohydrin,followed by reaction with the key intermediate 4-(2-methoxyethyl)phenol.4-(2-Methoxyethyl)phenol can be synthesized from phenylethanol,p-chlorophenol,phenol,p-hydroxyacetophenone,p-hydroxyphenylacetate methyl ester,p-nitrotoluene,and other raw materials.The synthesis of this intermediate from phenylethanol has the most industrial cases and the lowest cost,but it carries a high risk during the nitrification reaction.Due to the production of by-product metal salts and the challenges of waste treatment,there are fewer enterprises using the p-chlorophenol and phenol processes.The processes of hydroxyacetophenone and methyl p-hydroxyphenylacetate are still in the research stage and have certain development prospects.
关键词
S-美托洛尔/环氧氯丙烷/4-(2-甲氧基乙基)苯酚Key words
S-metoprolol/epichlorohydrin/4-(2-methoxyethyl)phenol引用本文复制引用
出版年
2024
NETL
NSTL
万方数据