Synthesis of a Novel Macrolide Antibiotic Tildipirosin for Animals
The target compound Tildipirosin in purity of 99.7％(HPLC)and overall yield of 60.1％was synthesized by Reductive amination,hydrolytic reaction,Iodization reaction,N-alkylation reaction from Tylosin,and the structure of the product was characterized by 1H NMR,13C NMR.The advantages of this procedure include less pollution,mild reaction condition and easy operation.Therefore it has a promising future in industrial application.
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