盐酸头孢吡肟精氨酸混粉工艺研究
Study on the Mixing Process of Cefepime Hydrochloride and Arginine Powder
田洪年 1申新辉 1孙志远 1梁丙辰 2胡利敏 1姜鹏鹏2
作者信息
- 1. 河北合佳医药科技集团股份有限公司,河北 石家庄 052165
- 2. 河北合佳医药科技集团股份有限公司,河北 石家庄 052165;河北合佳医药科技集团合佳研究院,河北石家庄 052165
- 折叠
摘要
以结晶温度、磨网孔径、混粉比例等条件为考察因素,盐酸头孢吡肟粒度为考察指标,优化了盐酸头孢吡肟精氨酸混粉工艺.优化的混粉工艺为:结晶温度9.0 ℃、磨网孔径1.0 mm、混粉比例1∶0.590、混粉转速8.1 r/min、混粉时间45 min、震荡强度65％.所得产品易于制剂分装,适用于工业化生产.
Abstract
The aim of the study is to optimize the mixing process of cefepime hydrochloride arginine powder.Using conditions such as crystallization temperature,mesh size,and mixing ratio as examination factors,and the particle size of cefepime hydrochloride as examination indicators,explore the optimal mixing conditions.The optimal mixing process is determined as follows:crystallization temperature of 9.0 ℃,grinding mesh aperture of 1.0 mm,mixing ratio of 1∶0.590,mixing speed of 8.1 r/min,mixing time of 45 minutes,and vibration strength of 65％.The product obtained by this process is easy to package and suitable for industrial production.
关键词
盐酸头孢吡肟/精氨酸/混粉/正交试验/响应面Key words
cefepime hydrochloride/arginine/mixing powder/orthogonal experiment/response surface引用本文复制引用
出版年
2024
NETL
NSTL
维普
万方数据