红霉素肟硅醚化绿色工艺研究
Research on the Green Process of Siletherization of Erythromycin Oxime
单继雷 1汤旗 1曹塞北 1金勇 1卢标华 1李广青1
作者信息
- 1. 浙江国邦药业有限公司,浙江上虞 312369
- 折叠
摘要
研究了红霉素肟硅醚化绿色合成工艺.以红霉素A肟为原料,盐酸甲醇为催化剂,进行硅醚化反应,并优化了反应条件.优化条件下,硅醚化反应收率96.4％,产品纯度94.4％.该工艺可以替代现有盐酸吡啶为催化剂的硅烷化反应,达到绿色合成、降低原辅料成本、并减少三废的目的,适合工业化生产.
Abstract
The research aims to develop a green synthesis method for the silicon etherification of erythromycin oxime.Using erythromycin A oxime as the raw material and methanol hydrochloride as the catalyst,the silicon etherification reaction was carried out and the reaction conditions were optimized.After optimization,the yield of silicon etherification reaction was 96.4％and the purity of the product was 94.4％.This process offers a sustainable alternative to silanization reaction with pyridine hydrochloride as catalyst,achieving green synthesis,reducing raw material costs,minimizing waste,and making it suitable for industrial production.
关键词
红霉素A肟/硅醚化反应/盐酸甲醇/绿色合成Key words
erythromycin A oxime/silicon etherification reaction/methanol hydrochloride/green synthesis引用本文复制引用
出版年
2024
NETL
NSTL
维普
万方数据