Research on the Green Process of Siletherization of Erythromycin Oxime
The research aims to develop a green synthesis method for the silicon etherification of erythromycin oxime.Using erythromycin A oxime as the raw material and methanol hydrochloride as the catalyst,the silicon etherification reaction was carried out and the reaction conditions were optimized.After optimization,the yield of silicon etherification reaction was 96.4％and the purity of the product was 94.4％.This process offers a sustainable alternative to silanization reaction with pyridine hydrochloride as catalyst,achieving green synthesis,reducing raw material costs,minimizing waste,and making it suitable for industrial production.
erythromycin A oximesilicon etherification reactionmethanol hydrochloridegreen synthesis
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