Study on the Optimization of Synthesis Conditions and Antibacterial Activity of Cephalosporin Derivatives
The study is dedicated to develop cephalosporin derivatives to overcome bacterial resistance.Through a systematic investigation of the synthesis pathways,the efficiency of cephalosporin derivative synthesis and product quality under various reaction conditions,including reaction temperature,time,and the amount of material,were explored.The optimal synthesis conditions were identified as reaction temperature of 25 ℃,reaction time of 2 h,and 0.15 mol of 7-AC A.The antibacterial efficacy of the synthesized cephalosporin derivatives was evaluated through inhibition zone diameter testing and minimum inhibitory concentration(MIC)experiments,demonstrating significant antibacterial activity against Staphylococcus aureus and Escherichia coli.Although the antibacterial potency of these derivatives requires further enhancement compared to the existing antibiotics,they show considerable potential in expanding the antibacterial spectrum and overcoming bacterial resistance.The structure of the synthesized product was characterized,and its molecular formula can be deduced as C17H19N5O5S.
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