金樱子叶的化学成分研究

A Study on the Chemical Constituents From Leaves of Rosa laevigata Michx.

何艳妮 ¹赵晓佳 ¹门靖 ²景莎莎³

扫码查看

作者信息

1. 西安国际医学中心医院,陕西西安 710100
2. 西安万隆制药股份有限公司,陕西西安 710119
3. 陕西中医药大学第二附属医院,陕西咸阳 712000
折叠

摘要

采用大孔树脂色谱、ODS色谱、凝胶色谱等现代色谱分离技术对金樱子叶的75％乙醇提取物进行分离纯化,根据理化性质和波谱数据鉴定化学结构.从金樱子叶75％乙醇提取物中分离得到了 8个化合物,分别鉴定为3-氧-α-紫罗兰醇-β-D-吡喃葡萄糖苷(1)、7,8-二氢-3-氧-α-紫罗兰醇-β-D-吡喃葡萄糖苷(2)、9-hydroxymengastigman-5-en-4-one-0-primeveroside(3)、4-氧-β-紫罗兰醇-β-D-吡喃葡萄糖苷(4)、7,8-二氢-4-氧-β-紫罗兰醇-β-D-吡喃葡萄糖苷(5)、甲基间苯三酚-β-D-吡喃葡萄糖苷(6)、没食子酸乙酯(7)、对羟基肉桂酸乙酯(8),化合物1、2、3、5为首次从蔷薇属植物中分离得到.研究金樱子叶的化学成分,为进一步阐明其药理机制奠定基础.

Abstract

The 75％ethanol extract of the leaves of Rosa laevigata Michx.were separated and purified by modern chromatography separation technologies such as macroporous resin chromatography,ODS chromatography,gel chromatography,etc.The identification of chemical structure was based on physical and chemical properties as well as spectral data.Eight compounds were obtained:3-oxo-α-ionol-β-D-glucopyranoside(1),7,8-dihyd-3-oxo-α-ionol-β-D-glucopyranoside(2),9-hydroxymengastigman-5-en-4-one-O-primeveroside(3),4-oxo-β-ionol-β-D-glucopyranoside(4),7,8-dihyd-4-oxo-β-ionol-β-D-glucopyranoside(5),methyl phloroglucinol-β-D-glucopyranoside(6),ethyl gallate(7),p-hydroxyl ethyl cinnamate(8).Compounds 1、2、3、5 were isolated from genus Rosa for the first time.Studying the chemical composition of the leaves of Rosa laevigata Michx.lays the foundation for future research on its pharmacological mechanism.

关键词

金樱子叶/化学成分/分离鉴定/紫罗兰醇

Key words

leaves of Rosa laevigata Michx./chemical constituents/isolation and identification/the ionol

引用本文复制引用

出版年

2024

精细化工中间体

湖南化工研究院

精细化工中间体

CSTPCD

影响因子：0.236

ISSN：1009-9212

段落导航