Review on Synthesis of Irbesartan and Its Key Intermediates
The synthesis of Irbesartan was documented.The method of using the 1-aminocyclopentyl formamide to preparation of Irbesartan is still the most common process.The approach involves synthesizing azospira,followed by reacting it with 4'-bromomethyl-2-cyanobiphenyl to produce Irbesartan.The glycine methyl ester hydrochloride process,valeramide process and p-bromobenzylamine process belong to the post-synthesis of azospira.These methods are still in developmental stages and require further research.
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