厄贝沙坦及其关键中间体的合成方法述评
Review on Synthesis of Irbesartan and Its Key Intermediates
薛菲1
作者信息
- 1. 西安医学高等专科学校,陕西西安 710309
- 折叠
摘要
综述了厄贝沙坦的合成工艺,使用1-氨基环戊基甲酰胺法先合成氮杂螺环、再与4'-溴甲基-2-氰基联苯对接合成厄贝沙坦的工艺仍然是使用最普遍的路线.甘氨酸甲酯盐酸盐工艺、戊酰胺工艺以及对溴苄胺工艺属于后合成氮杂螺环工艺,尚不成熟,有待进一步研究.
Abstract
The synthesis of Irbesartan was documented.The method of using the 1-aminocyclopentyl formamide to preparation of Irbesartan is still the most common process.The approach involves synthesizing azospira,followed by reacting it with 4'-bromomethyl-2-cyanobiphenyl to produce Irbesartan.The glycine methyl ester hydrochloride process,valeramide process and p-bromobenzylamine process belong to the post-synthesis of azospira.These methods are still in developmental stages and require further research.
关键词
厄贝沙坦/氮杂螺环/1-氨基环戊基甲酰胺Key words
Irbesartan/nitrogen spirocyclic ring/1-aminocyclopentyl formamide引用本文复制引用
出版年
2024
NETL
NSTL
万方数据