Synthesis of 2-Amino-5-fluoro-3',4'-dichlorobiphenyl by Suzuki Coupling Catalyzed by Pd-organophosphine
Using 3,4-dichlorophenylboronic acid and 2-bromo-4-fluoroaniline as raw materials,a Pd-organophosphine composite catalyst was used for Suzuki coupling reaction under alkaline conditions,and 2-amino-5-fluoro-3'4'-dichlorobiphenyl was obtained after separation and reduced pressure concentration.The results under different reaction conditions were analyzed,and the optimized conditions were:toluene and water as mixed solvents,n(2-bromo-4-fluoroaniline)∶n(3,4-dichlorophenylboronic acid)∶n(K2CO3)∶n(composite catalyst)=1∶1.2∶1.2∶0.000 5,the reaction temperature was 85 ℃,the reaction time was 4 h,the purity was 98.0％,and the yield was greater than 97.0％.The method requires less catalyst,has a simple process,and has a high product yield.It conforms to the concept of green chemical production and has industrial prospects.
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