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活性炭吸附右旋糖酐40原料药中细菌内毒素的研究

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为了降低右旋糖酐40原料药的细菌内毒素含量,研究了不同种类和用量的活性炭在不同温度和吸附时间下对原料药中细菌内毒素的吸附情况.结果表明:选用药用活性炭用量2%、加热温度75~85 ℃、加热时间(30+5)min是降低右旋糖酐40原料药细菌内毒素含量的较佳工艺条件.
Effect of Activated Carbon on the Bacterial Endotoxin Content of Dextran 40 API
To reduce the bacterial endotoxin content of Dextran 40 API,the adsorption of bacterial endotoxin in API by different types and amounts of activated carbon at different temperatures and time was investigated.The results showed that the optimal process conditions for reducing the bacterial endotoxin content of Dextran 40 API were using 2%of medicinal activated carbon,a heating temperature of 75~85 ℃ and a heating time of(30±5)min.

Dextran 40 APIbacterial endotoxinactivated carbonadsorption

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新乡医学院药学院,河南新乡 453000

西安万隆制药股份有限公司,陕西杨凌 712100

右旋糖酐40原料药 细菌内毒素 活性炭 吸附

2024

精细化工中间体
湖南化工研究院

精细化工中间体

CSTPCD
影响因子:0.236
ISSN:1009-9212
年,卷(期):2024.54(6)