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HPLC法测定注射用头孢他啶的含量

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建立一种高效液相色谱法(HPLC)测定注射用头孢他啶含量.经过验证:该方法的系统精密度(峰面积RSD)为0.19%(n=6),重复性(RSD)为0.12%,中间精密度(RSD)为1.38%,线性范围为61.295 5~214.534 3 μg/mL,平均回收率为101.30%(RSD为0.25%).该方法专属性、精密度、线性、耐用性等参数符合要求,可用于测定注射用头孢他啶的含量.
Determination of the Ceftazidime for Injection by HPLC
A HPLC method was established for determining the content of the Ceftazidime for injection.The systematic precision(peak area RSD)of the method was 0.19%(n=6),the repeatability(RSD)was 0.12%and the intermediate precision(RSD)was 1.38%,the linear range was from 61.295 5 μg/mL to 214.534 3 μg/mL,the average recovery rate was 101.30%,with the RSD of 0.25%.The specificity,precision,linearity and robustness of the method meet the requirements,and can be used to determine the content of the Ceftazidime for injection.

contentCeftazidime for injectionHPLCmethodological verification

谷海泽、表亚囡、焦云飞、杨轩、巩海雪、杨梦德、谷艺凡

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华北制药河北华民药业有限责任公司河北省头孢类药物制备技术创新中心,河北石家庄 052165

含量 注射用头孢他啶 高效液相色谱法 方法学验证

2024

精细化工中间体
湖南化工研究院

精细化工中间体

CSTPCD
影响因子:0.236
ISSN:1009-9212
年,卷(期):2024.54(6)