Investigation and Analysis of the Treatment Outcome and Current Status of Multidrug-resistant Tuberculosis Patients Discovered in Zhuhai City from 2014 to 2019
Objective:Zhuhai began to implement the standardized treatment and management of MDR-PTB on September 1,2013.This paper evaluates the effectiveness of the standardized management of MDR-PTB in Zhuhai by investigating and analyzing the treatment outcomes and status quo of 116 cases of MDR-PTB patients found in our city from 2014 to 2019.It provides a theoretical basis for the revision of the implementation plan of MDR-PTB project in our city.The diagnosis and treat-ment data of 116 MDR-PTB patients found in our city from 2014 to 2019 were retrospectively ana-lyzed,and the disease outcome of patients was judged by bacteriological and imaging examination data combined with medical history.The diagnosis and treatment status of patients was evaluated by telephone interviews,home visits and questionnaires.SPSS software was used for statistical process-ing and analysis,and the implementation effect of MDR-PTB standardized treatment management project in our city was scientifically researched and analyzed.Results:Out of the 116 patients,45 cases(38.79% )were included in the standardized MDR-PTB treatment management program;31cases(37.8% )were treated with standard multidrug resistance;46 cases(56.10% )were suc-cessfully treated,including 38 cases cured and 8 cases who completed the course of treatment.Treatment failed in 19 patients(16.37% ),including 9 cases that were not cured due to non-stand-ard anti-MDR-PTB treatment,5 cases that were not cured due to extensive drug resistance,and 5 deaths directly related to MDR-PTB.There were 20 cases(26.64% )of uncured patients,including 14 cases of treatment failure(excluding 5 directly related to tuberculosis),and 6 who refused anti-MDR-PTB treatment.12 patients(10.34% )died,with 5 deaths directly related to MDR-PTB,and 7 related to non-tuberculosis-related illnesses(including 3 specifically linked to malignant tumors).38 cases(32.76% )were lost to follow-up,including 15 cases after referral,21 cases af-ter anti-MDR-PTB treatment,and 2 long-term refusals of MDR-PTB treatment when diagnosed of MDR-PTB.In 12 cases of extensively drug-resistant tuberculosis(XDR-PTB),2 cases were cured,3 cases died,5 cases were treated with anti-MDR-PTB antimicrobial therapy and 2 cases were lost to follow-up.Conclusion:The implementation of the standardized treatment management project of MDR-PTB in our city is slow,and the inclusion rate,normative treatment rate,comple-tion rate and cure rate of MDR-PTB patients are low,while the rate of lost to follow-up is high.Through the evaluation of the implementation of the standardized treatment and management project of MDR-TB in our city,the weak points of the implementation of the project are identified,and the theoretical basis is provided for the revision of the implementation plan of the standardized treatment and Management project of MDR-TB in Zhuhai.
Tuberculosis(TB)multidrug resistantextensively drug-resistantmultidrug-resistant pulmonary tuberculosis(MDR-PTB)extensively drug-resistant tuberculosis(XDR-TB)treat-ment rate of included itemscompletion rate of treatment coursecuretreatment success
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