In order to improve the comprehensive performance of beam-column material drilling and milling machining center,the tool rest with X and Y direction interpolation movement as the object is taken to carry out the lightweight design.The tool rest mass was optimized twice.In the first optimization,topology algorithm was used to establish a topology optimization model with the maximum stiffness as the objective function,stress and strain as constraints,and mass as response constraints.For the second time,MOGA algorithm was used to optimize the tool rest on the basis of topology optimization,and a topology optimization tool rest reconstruction model was established to verify mechanical properties and low order natural frequencies.Optimization design variables were selected,and CCD(Central composite design)experiment was designed to obtain initial sample points.Five verification points were selected to fit the predicted values via Kriging model.A response surface model with high local sensitivity was established according to Kriging model to obtain the influence of the design variables on the stress,deformation and mass.An optimization model was established by using the MOGA algorithm to find the optimal solution.The test results show that the tool rest mass is reduced by 14.48%after two quality optimization designs under the satisfying strength.