The effects of different concentrations of 6 - BA on the growth, POD activity and adversity resistance of melon seedlings were studied. The results showed that it got good effect when 6 - BA concentration was 50 mg/L or 30 mg/L, especially applying 50 mg/L 6 - BA got the best comprehensive effect, it could not only significantly increase the POD activity, but also obviously restrain the root growth of melon seedlings, thus it could enhance the resistance of melon seedlings to outside adversity. Moreover, applying 20 ~ 30 mg/L 6 - BA also had better comprehensive effect and greater inhibitory action to the growth of melon seedlings.