摘要
肺癌是当今最常见的恶性肿瘤之一，各国的肺癌发病率和病死率近年都有明显增高趋势。肺癌高发与吸烟、空气污染、职业暴露、精神、遗传、饮食以及既往慢性肺部疾病等风险因素有关。本文介绍了几种常见的慢性肺部疾病，包括慢性阻塞性肺疾病、肺结核、特发性肺纤维化、硅沉着病等，总结了其与肺癌的关系，并试图阐明引起肺癌的可能的分子生物学机制，为探讨肺癌的病因提供依据。
Abstract
Lung cancer is one of the most common malignant tumors.In the recent decades,the incidence and mortality of lung cancer have significantly increased in all countries.The high inci-dence of lung cancer is associated with smoking,air pollution,occupational exposure,mental stress,heredity,diet and chronic lung diseases.This review introduces several common chronic lung diseases,including chronic obstructive pulmonary diseases,tuberculosis,idiopathic pulmona-ry fibrosis,silicosis,etc.In addition,this paper summarizes the relationship of chronic lung disea-ses to lung cancer and attempts to clarify the molecular biological mechanisms,which can provide a basis for investigating the etiology of lung cancer.
基金项目
国家自然科学基金(31200581)
浙江省自然科学基金一般项目(LY15H160068)
杭州市科技计划发展项目(20120633B26)
杭州师范大学本科生创新能力提升工程(CX2013108)
杭州师范大学本科生创新能力提升工程(CX2013106)
杭州师范大学挑战杯(1183XXW174)
杭州师范大学挑战杯(1283XXM167)
浙江省新苗人才计划(2014R421038)
NETL
NSTL
维普
万方数据