Network Meta-analysis of Six Traditional Chinese Medicine Injections in Post-stroke Depression Treatment
Objective To investigate therapeutic effects of traditional Chinese medicine injec-tions on post-stroke depression(PSD)through network meta-analysis.Methods Chinese and English databases,including China National Knowledge Infrastructure(CNKI),Wanfang Data,Wipu,China Biomedical Literature,PubMed,Web of Science and Cochrane Library,were searched to collect relevant studies.Literature data that met the inclusion criteria were reviewed and extrac-ted,quality assessment was performed using the Cochrane Risk of Bias Assessment Tool,and data analysis was performed using RevMan 5.4.1,Stata 15.1,and the R software gemtc package.Results A total of 14 studies were included,involving six Chinese medicine injections,namely,Ciwujia In-jection,Yinxing Damo Injection,Xingnaojing Injection,Tianmasu Injection,Ginkgolides Glu-cosamine Injection,and Xuesaitong Injection.Network meta-analysis showed that in terms of the total effective rate,the top three traditional Chinese medicine injections were Tianmasu Injection,Xingnaojing Injection,and Yinxing Damo Injection;in terms of Hamilton Depression Scale(HAMD)scores,the top three traditional Chinese medicine injections were Xingnaojing Injection,Ciwujia Injection,and Xuesaitong Injection;in terms of Depression Self-assessment Scale(SDS)scores,the top three traditional Chinese medicine injections were Xingnaojing Injection,Yinxing Damo Injection,and Tianmasu Injection.During the course of treatment,no serious adverse reac-tions were observed for any of the six herbal injections.Conclusion Traditional Chinese medicine injections combined with conventional Western medicine can improve the efficacy of treating post-stroke depression and improve neurological function and daily living ability,with the best overall therapeutic effect being achieved with Xingnaojing Injection.
post-stroke depressiontraditional Chinese medicine injectionsnetwork meta-analysis
万方数据
维普
