Association between Maternal Trace Element Status and Gestational Diabetes Mellitus during Pregnancy
Objective To investigate the effect of plasma levels of six trace elements(Zn,Ca,Fe,Cu,Mg and Se)on the risk of developing gestational diabetes mellitus(GDM)and on blood glucose levels.Methods One hundred and twenty two pregnant women,who received their first antenatal visit in Hunan Maternal and Child Health Hospital from October 2019 to October 2021,were selected to participate in the cohort study,including 61 pregnant women with GDM(GDM group)and 61 healthy pregnant women(control group).Blood samples were collected at the first prenatal visit in both groups,and the concentrations of Zn,Ca,Fe,Cu,Mg,and Se in plasma were determined.The associations between plasma trace element concentrations and the risk of GDM,as well as the correlations between blood glucose levels and trace element concentrations,were analyzed by conditional logistic regression models.Results The plasma concentrations of Fe and Cu in the GDM group were significantly higher(P＜0.01)than those in the control group,where-as the plasma concentrations of Zn,Ca and Se were significantly lower(P＜0.01)than those in the control group.High levels of Fe(OR=4.56,95%CI:2.68,7.79)and Cu(OR=2.48,95%CI:1.48,4.16)in plasma were associated with increased risk of GDM;high levels of Zn(OR=0.29,95%CI:0.17,0.49)and Ca(OR=0.50,95%CI:0.30,0.83)in plasma were associated with significantly lower risk of GDM.Multifactorial analysis after adjusting for major confounders showed that plas-ma Zn levels were negatively correlated with 1 h-load blood glucose(PBG)(β=-0.16,95%CI:-0.11,-0.04)and 2 h-PBG(β=-0.16,95%CI:-0.10,-0.04)blood glucose levels;plasma Ca levels were negatively correlated with fasting blood glucose levels(adjustedβ=-0.11,95%CI:-0.23,-0.04),but the correlation was weak;plasma Fe levels were positively correlated with both 1 h-PBG(adjustedβ=0.13,95%CI:0.04,0.17)and 2 h-PBG levels(adjustedβ=0.09,95%CI:0.01,0.12).Conclusion Maternal plasma levels of Zn,Ca,Fe and Cu can be significantly asso-ciated with the risk of GDM in early pregnancy,and elevated Fe and Cu levels can be associated with elevated blood glucose levels.
万方数据
维普
