Application of PET-CT Combined with Endoplasmic Reticulum Stress Marker Detection in Evaluation of Chemotherapeutic Efficacy and Prognosis of Non-Small Cell Lung Cancer
Objective To explore the application of PET-CT combined with endoplasmic retic-ulum stress(ERS)marker detection in the evaluation of chemotherapeutic efficacy and prognosis of non-small cell lung cancer(NSCLC).Methods Clinical data of 84 patients who were pathologi-cally diagnosed with NSCLC by Department of Radiotherapy,Tangshan People's Hospital,from September 2017 to June 2022 were analyzed retrospectively.The maximum 18 F-fluorodeoxyglu-cose(18 F-FDG)uptake(SUVmax)was quantitatively evaluated by PET/CT.Serum levels of trib-bles homologous protein 3(TRB3),glucose regulatory protein 78(GRP78)and C/EBP homolo-gous protein(CHOP)were determined by ELISA.The correlation between SUVmax and ERS markers and the correlation between the markers and therapeutic response were evaluated.In ad-dition,the optimal cutoff values of SUVmax and ERS markers for identifying therapeutic response were obtained using the receiver operating characteristic(ROC)curve.Results The SUVmax was obviously correlated with the levels of CHOP(r=-0.284,P=0.007)and TRB3(r=0.387,P= 0.005),but was not related to the level of GRP78(r=0.086,P=0.443).Among the 84 NSCLC patients,CR,PR,SD and PD occurred in 2(2.4%),43(51.2%),34(40.5%)and 5(6.0%),respec-tively.Multivariate analysis showed that SUVmax(OR:1.217;95%CI:1.090-1.525;P =0.002),CHOP(OR:0.140;95%CI:0.062-0.454;P＜0.001)and clinical stage(OR:1.283;95%CI:1.112-1.718;P=0.009)were the independent predictors of treatment response.With the SUV_CHOP scoring system,the objective remission rates of patients with scores of 0,1 and 2 were 90%(18/20),60.6%(20/33)and 22.6%(7/31),the median progression-free survivals were 18.9,13.6 and 10.6,and the median overall survivals were 28.3,19.4 and 13.4 months,respectively(P＜0.001).Conclusion In stage Ⅲ-Ⅳ NSCLC patients treated with first-line chemotherapy,SUVmax and CHOP are independent predictors of therapeutic response and prognosis,and the SUV_CHOP scoring system established by their combination has a good predictive value for therapeutic re-sponse and prognosis.
万方数据
维普
