Relationship between Preoperative Serum Endothelial TEK Tyrosine Kinase Level and Clinical Characteristics and Prognosis in Patients with Cervical Cancer
Objective To investigate the relationship between preoperative serum endothelial TEK tyrosine kinase(TIE2)level and clinical characteristics and prognosis in patients with cervi-cal cancer.Methods Clinical data of 346 patients who underwent radical surgery for cervical canc-er in our hospital between January 2013 and June 2022 were retrospectively analyzed.Ten cases were randomly selected for Olink proteomics analysis.Serum TIE2 levels were measured using immunoradiometric assay to analyze the relationship between TIE2 levels and clinical data.The cutoff value of serum TIE2 for tumor recurrence was calculated using the receiver operating char-acteristic(ROC)curve.Progression-free survival(PFS)and overall survival(OS)were analyzed u-sing the Kaplan-Meier method.Cox proportional hazard model was used to evaluate the factors af-fecting PFS and OS.Results Olink proteomics showed that TIE2,S100A4,MSLN,FGFBP1,ICOSLG and CASP8 were decreased after radical resection for cervical cancer(P＜0.05).Preoper-ative serum TIE2 level was correlated with FIGO stage,tumor size,deep myometrial invasion,LVSI,parametrial invasion,vaginal margin invasion,lymphatic metastasis,and extrapelvic recur-rence(P＜0.05).The area under the ROC curve was 0.768(95％CI=0.718～0.791,P＜0.001).The Youden index,sensitivity and specificity were 2.75 ng·mL-1,73.2％and 70.3％,respective-ly.The median PFS and OS in patients with serum TIE2 level≤2.75 ng·mL-1 were longer than those in patients with serum TIE2 level＞2.75 ng·mL-1(P＜0.001).Cox proportional hazard model showed that serum LVSI and TIE2 level＞2.75 ng·mL-1 were independent risk factors for PFS and OS in patients undergoing radical surgery for cervical cancer(P＜0.001).Conclusion Preoperative serum TIE2 level is associated with clinical characteristics of patients with cervical cancer,and patients with preoperative TIE2 level＞2.75 ng·mL-1 have a worse prognosis.
cervical cancerradical surgeryendothelial TEK tyrosine kinaseprognosis
万方数据
维普
