Resistance of Lenvatinib and Its Use in the Treatment of Hepatocellular Carcinoma:a Review
Lenvatinib is an effective first-line therapeutic agent for advanced hepatocellular car-cinoma.However,many patients experience disease progression after lenvatinib treatment,and the problem of drug resistance is prevalent in therapeutic practice,urgently requiring strategies to re-verse drug resistance.Numerous studies have shown that epigenetics,cell transport processes,tumor microenvironment,tumor dryness,as well as autophagy and ferroptosis,are closely related to the resistance mechanism of lenvatinib.This article summarizes the research progress on the mechanism of lenvatinib resistance in hepatocellular carcinoma,and preliminarily explores clinical treatment strategies to provide a theoretical basis for improving the prognosis of lenvatinib-resist-ant patients.
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