Cronkhite-Canada Syndrome:Two Case Reports and Review of the Literature
Objective To study the clinical characteristics,treatment and prognosis of Cronkhite-Canada syndrome(CCS).Methods Clinical data of two patients with CCS admitted to the Depart-ment of Gastroenterology of the Fourth Affiliated Hospital of Nanchang University were collect-ed,and their diagnosis and treatment,regression,and long-term gastrointestinal endoscopic fol-low-up data were analyzed in conjunction with relevant literature.Results Both cases were high-lighted by gastric polyp lesions.The first patient was diagnosed with CCS and colon cancer in May 2013,and was treated with endoscopic partial polypectomy;with nutritional support,the patient's status improved significantly;6 gastroscopic follow-ups were performed during the next 2 years;gastric sinus malignant ulceration was diagnosed in April 2015,and he died in July 2017.The sec-ond patient was admitted to the hospital in June 2019 with an unknown diagnosis;combined with other symptoms and signs,he was confirmed with CCS and treated with hormone therapy,but with poor result;total gastrectomy was performed due to the disease progression;he has been followed up for 2 years now,with his conditions stable.Conclusion CCS can become malignant with progressive exacerbation.Glucocorticosteroids are the mainstay of treatment,and resection of severe lesions can be considered when necessary.Long-term gastrointestinal endoscopic follow-up can be helpful in the diagnosis of the disease and the detection of early cancerous lesions.
万方数据
维普
