Serum Interleukin-7 in Patients with Chronic Liver Disease
Objective To investigate the levels and clinical significance of interleukin-7(IL-7)in serum and urine of patients with chronic liver disease at different stages,and to provide some references for the treatment of patients with liver disease.Methods A total of 147 serum and u-rine samples were collected from 123 participants:30 healthy individuals(Group A1),56 patients with chronic hepatitis(Group A2),and 37 patients with cirrhosis(Group A3).The samples were divided into 30 copies of Group A1(13 serum samples and 17 urine samples),64 copies of Group A2(24 serum samples and 40 urine samples),and 53 copies of Group A3(24 serum samples and 29 urine samples).The ELISA method was used to detect the IL-7 levels of the samples in each group;the fully automated biochemistry instrument was used to detect the albumin(ALB)levels of the serum samples in each group;the liver elasticity measurement and liver steatosis quantita-tive detection equipment was used to detect the liver elasticity hardness values(kPa value)of the subjects in each group and to analyze the correlation between the IL-7 levels and the ALB and kPa values.Results The serum IL-7 levels varied in the three groups(group A1＞group A2＞group A3);the difference between Group A1 and Group A3 was statistically significant(P＜0.05)and the difference between group A2 and group A1 and group A3 was not statistically significant(P＞0.05).The urinary IL-7 levels varied in the three groups(group A1＞group A2＞group A3),but none of the differences was statistically significant(P＞0.05).Further studies found that the ser-um IL-7 levels were significantly and positively correlated with the ALB levels(r=0.226,P=0.041);the serum IL-7 levels were significantly and negatively correlated with the liver elasticity hardness kPa values(r=-0.258,P=0.045);the urinary IL-7 levels showed a significant positive correlation with the serum ALB levels(r=0.221,P=0.046).Conclusion The serum IL-7 levels tended to decrease with the progression of chronic liver disease.The IL-7 levels could be closely associated with liver fibrosis and might have the potential to delay or inhibit liver fibrosis.
NETL
NSTL
万方数据
