基于fNIRS的主动、被动与想象屈肘运动脑激活的特点及比较
Brain Activation in Active,Passive and Imaginary Elbow Flexion Movements:an fNIRS Study
喻多多 1魏聪惠 2罗军2
作者信息
- 1. 南昌大学第二附属医院康复医学科,南昌 330006;南昌医学院临床医学院,南昌 330036
- 2. 南昌大学第二附属医院康复医学科,南昌 330006
- 折叠
摘要
目的 利用功能性近红外光谱成像(functional near-infrared spectroscopy,fNIRS)技术探究健康成年人主动屈肘、被动屈肘和想象屈肘运动脑激活的特点.方法 选取30名健康大学生为被试者,男女各15例,年龄(21.22±1.42)岁,选择右手主动、被动和想象屈肘任务作为刺激模式,采用近红外光谱脑功能成像系统实时采集被试者3种不同运动模式下脑功能区氧合血红蛋白(Oxyhemoglobin,HbO2)水平作为脑激活的特征值,并以静息态(resting state,RS)的HbO2水平为基线值,比较3种运动模式下脑激活的特点.结果 非参数检验结果表明,不同运动模式下,右侧初级运动皮层(H=13.309,P=0.004),右侧前额叶前部皮层(H=20.30,P＜0.001),右侧背外侧前额叶皮层(H=12.194,P=0.007),左侧初级体感皮层(H=12.642,P=0.005),左侧初级运动皮层(H=20.03,P＜0.001),左侧前额叶前部皮层(H=18.187,P＜0.001),左侧背外侧前额叶皮层(H=13.379,P=0.004)的HbO2水平比较差异有统计学意义;而其右侧初级体感皮层(H=4.284,P=0.232),右侧前运动区和辅助运动皮层(H=4.201,P=0.241),左侧前运动区和辅助运动皮层(H=8.793,P=0.052)HbO2水平比较差异无统计学意义.结论 不同运动模式下存在特定的脑功能区激活,其激活程度既有相似性又有差异性,主动运动和被动运动任务下的脑激活区最类似.
Abstract
Objective To investigate the characteristics of brain activation in active elbow flex-ion,passive elbow flexion and imaginary elbow flexion in healthy adults using functional near-in-frared spectroscopy(fNIRS).Methods 30 healthy college students were selected as subjects,15 of each gender,aged(21.22±1.42)years old.Active,passive and imaginary elbow flexion tasks on the right hand were selected as stimulation paradigms,and fNIRS was used to collect real-time oxyhemoglobin(HbO2)concentrations in brain functional areas under three different motor para-digms as the characteristic values of brain activation.The resting state HbO2 concentration was used as the baseline value to compare the characteristics of brain activation under the three differ-ent motor paradigms.Results The nonparametric test results showed that under different motor paradigms,there were statistically significant differences in HbO2 levels in the right primary mo-tor cortex(H=13.309,P=0.004),the right prefrontal anterior cortex(H=20.30,P＜0.001),the right dorsolateral prefrontal cortex(H=12.194,P=0.007),the left primary somatosensory cor-tex(H=12.642,P=0.005),the left primary motor cortex(H=20.03,P＜0.001),left anterior prefrontal cortex(H=18.187,P＜0.001),and left dorsolateral prefrontal cortex(H=13.379,P=0.004);however,there were no statistically significant differences in the right primary somato-sensory cortex(H=4.284,P=0.232),the right anterior motor cortex and auxiliary motor cortex(H=4.201,P=0.241),and the left anterior motor cortex and auxiliary motor cortex(H=8.793,P=0.052).Conclusion There are specific functional brain regions activated under different motor paradigms,with both similarities and differences in the degree of activation,with the most similar brain activated regions in active and passive movement tasks.
关键词
功能性近红外光谱成像技术/主动运动/被动运动/想象运动/氧合血红蛋白/脑功能区/脑激活Key words
functional near-infrared spectroscopy/active movement/passive movement/imaginary movement/oxyhemoglobin/functional brain region/brain activation引用本文复制引用
基金项目
国家重点研发计划项目(2020YFC2005800)
江西省教育厅科学技术研究项目(GJJ2189300)
出版年
2024
NETL
NSTL
万方数据