Perioperative Application of Two Balloon-based Vascular Interventional Surgeries in Lower Extremity Arteriosclerosis Obliterans:a Comparison of Clinical Efficacy
Objective To investigate the use of different balloons in the treatment of lower ex-tremity arteriosclerosis obliterans(ASO).Methods A total of 106 patients with ASO who under-went vascular interventional surgery from June 2020 to June 2022 were selected for the study and were divided into the observation group and the control group,each with 53 cases,by using the computerized randomization method.Drug-coated balloons were used intraoperatively in the ob-servation group and plain balloons were used intraoperatively in the control group.Clinical effica-cy,oxidative stress indices[superoxide dismutase(SOD),thioredoxin(TRX),myeloperoxidase(MPO),malondialdehyde(MDA)],prethrombotic state-related indicators[thrombus precursor protein(TpP),vascular pseudohaemophilic factor(vWF),total homocysteine(tHcy)],ankle-bra-chial index(ABI),internal diameter of target artery,Rutherford classification,and complication occurrence were compared in both groups.Results The total effective rate of the observation group(92.45％)was significantly higher than that of the control group(77.36％)(P＜0.05);SOD and TRX levels of the observation group were higher than those of the control group whereas MPO and MDA levels were lower than those of the control group at 3 and 7 d postoperatively(P＜0.05);the levels of TpP,vWF,and tHcy were lower than those of the control group at 3 and 7 d postoperatively(P＜0.05);the ABI and target arterial vascular diameter of the observation group were higher than those of the control group at 3 and 7 d postoperatively(P＜0.05);Ruther-ford grading distribution of the observation group was better than that of the control group at 12 months after surgery(P＜0.05);the difference in the total incidence of complications between the 2 groups was not statistically significant(P＞0.05).Conclusion Both balloon-based vascular in-terventional surgeries for treating patients with ASO can have a good safety profile,but the drug-coated balloon might enhance the efficacy,reduce oxidative stress,improve the prethrombotic state,restore blood flow,and improve the patient's prognosis.
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