The Causal Relationship between Liposomes and Osteoporosis Based on Mendelian Randomization Analysis
Objective To investigate the causal relationship between liposomes and osteoporosis(OP)using the two-sample Mendedian randomization analysis(MR)based on public data from the genome-wide association study(GWAS).Methods Using the MR method,895 liposomes were screened for associated single nucleotide polymorphisms(SNPs)from the GWAS database as instrumental variables(IVs),and the inverse variance weighting(IVW)was used as the main analysis method,supplemented by the model selection method(MR Egger),the weighted median,the simple model and the weighted model,combined with sensitivity analysis to comprehensively assess the causal relationship between liposomes and OP.Results Triglycerides(48:0)(OR=1.121 1,95%CI:1.019 1 to 1.233 2,P=0.018 9)and triglycerides(48:3)(OR=1.130 2,95%CI:1.042 2 to 1.225 6,P=0.003 1)might increase the risk of OP development;ceramides(d40:1)(OR=0.923 3,95%CI:0.853 8 to 0.998 6,P=0.046 0),phosphatidylcholine(16:1_18:2)(OR=0.932 2,95%CI:0.882 7 to 0.984 5,P=0.0117),phosphatidylcholine(O-17:0_15:0)(OR=0.938 6,95%CI:0.881 9 to 0.999 1,P=0.046 6),phosphatidylcholine(16:0_18:2)(OR=0.914 2,95%CI:0.839 9 to 0.995 1,P=0.038 0),and triglycerides(51:4)(OR=0.919 8,95%CI:0.854 0 to 0.990 5,P=0.026 9)were associated with a reduced risk of developing OP.Conclusion Our study suggests that there is a causal relationship between liposomes and OP.Triglycerides(48:0)and Triglycerides(48:3)may be potential risk factors for OP;ceramides(d40:1),phosphatidylcholine(16:1_18:2),phosphatidylcholine(O-17:0_15:0),phosphatidylcholine(16:0_18:2),and triglycerides(51:4)may be potential protective factors,suggesting that liposome-based interventions have the potential to prevent and treat OP.
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