基于孟德尔随机化分析脂质体与骨质疏松症之间的因果关系
The Causal Relationship between Liposomes and Osteoporosis Based on Mendelian Randomization Analysis
蒲张林 1陈锋1
作者信息
- 1. 广西中医药大学研究生院,南宁 530001
- 折叠
摘要
目的 通过全基因组关联研究数据(genome-wide association study,GWAS)的公共数据来进行双样本孟德尔随机化(Mendedian randomization analysis,MR)分析,探究脂质体与骨质疏松症(osteoporosis,OP)之间的因果关系.方法 使用MR方法,从GWAS数据库筛选895种脂质体的相关单核苷酸多态性(single nucleotide polymorphisms,SNPs)作为工具变量(IVs),以逆方差加权(IVW)为主要分析方式,辅以模型选择法(MR Egger)、加权中位数、简单模式和加权模式,结合敏感性分析综合评估脂质体与OP之间的因果关系.结果 甘油三酯(48∶0)(OR=1.121 1,95%CI:1.019 1～1.233 2,P=0.018 9)、甘油三酯(48:3)(OR=1.130 2,95%CI:1.042 2～1.225 6,P=0.003 1)可能增加OP发病的风险;神经酰胺(d40:1)(OR=0.923 3,95%CI:0.853 8～0.998 6,P=0.046 0)、磷脂酰胆碱(16∶1_18:2)(OR=0.932 2,95%CI:0.882 7～0.984 5,P=0.011 7)、磷脂酰胆碱(O-17:0_15:0)(OR=0.938 6,95%CI:0.881 9～0.999 1,P=0.046 6)、磷脂酰胆碱(16:0_18:2)(OR=0.914 2,95%CI:0.839 9～0.995 1,P=0.038 0)、甘油三酯(51:4)(OR=0.919 8,95%CI:0.854 0～0.990 5,P=0.026 9)与OP发病风险降低有关.结论 脂质体与OP之间存在因果关系.甘油三酯(48:0)甘油三酯(48:3)可能是OP潜在的危险因素,神经酰胺(d40:1)、磷脂酰胆碱(16:1_18:2)、磷脂酰胆碱(O-17:0_16:0)、磷脂酰胆碱(16:0_18:2)、甘油三酯(51:4)可能是OP潜在的保护因素,提示基于脂质体的干预有着预防和治疗OP的潜力.
Abstract
Objective To investigate the causal relationship between liposomes and osteoporosis(OP)using the two-sample Mendedian randomization analysis(MR)based on public data from the genome-wide association study(GWAS).Methods Using the MR method,895 liposomes were screened for associated single nucleotide polymorphisms(SNPs)from the GWAS database as instrumental variables(IVs),and the inverse variance weighting(IVW)was used as the main analysis method,supplemented by the model selection method(MR Egger),the weighted median,the simple model and the weighted model,combined with sensitivity analysis to comprehensively assess the causal relationship between liposomes and OP.Results Triglycerides(48:0)(OR=1.121 1,95%CI:1.019 1 to 1.233 2,P=0.018 9)and triglycerides(48:3)(OR=1.130 2,95%CI:1.042 2 to 1.225 6,P=0.003 1)might increase the risk of OP development;ceramides(d40:1)(OR=0.923 3,95%CI:0.853 8 to 0.998 6,P=0.046 0),phosphatidylcholine(16:1_18:2)(OR=0.932 2,95%CI:0.882 7 to 0.984 5,P=0.0117),phosphatidylcholine(O-17:0_15:0)(OR=0.938 6,95%CI:0.881 9 to 0.999 1,P=0.046 6),phosphatidylcholine(16:0_18:2)(OR=0.914 2,95%CI:0.839 9 to 0.995 1,P=0.038 0),and triglycerides(51:4)(OR=0.919 8,95%CI:0.854 0 to 0.990 5,P=0.026 9)were associated with a reduced risk of developing OP.Conclusion Our study suggests that there is a causal relationship between liposomes and OP.Triglycerides(48:0)and Triglycerides(48:3)may be potential risk factors for OP;ceramides(d40:1),phosphatidylcholine(16:1_18:2),phosphatidylcholine(O-17:0_15:0),phosphatidylcholine(16:0_18:2),and triglycerides(51:4)may be potential protective factors,suggesting that liposome-based interventions have the potential to prevent and treat OP.
关键词
孟德尔随机化/脂质体/骨质疏松症Key words
Mendelian randomization/liposomes/osteoporosis引用本文复制引用
基金项目
国家自然科学基金地区科学基金项目(82360936)
出版年
2024
NETL
NSTL
万方数据