Expression Level of Serum IL-33 in Patients with Alzheimer's Disease,Mild Cognitive Impairment and Subjective Cognitive Decline and its Clinical Significance
Objective To compare the levels of serum interleukin-33(IL-33)in patients with Alzheimer's disease(AD),mild cognitive impairment(MCI)and subjective cognitive decline(SCD),to explore the correlation between IL-33 and cognitive function,and to evaluate the diagnostic value of serum IL-33.Methods In this case-control study,46 patients with AD,42 patients with MCI,51 patients with SCD and 50 healthy participants(Health Control)were selected from the Second Affiliated Hospital of Xinjiang Medical University.Neuropsychological assessment was performed on all the subjects and serum IL-33 levels were measured by ELISA.The general information and peripheral blood routine biochemical data of the 4 groups were compared respectively,and the correlation between the serum IL-33 level and the scores of the Mini Mental State Examination(MMSE)and the Montreal Cognitive Assessment(MoCA)was analyzed.The risk factors of AD were analyzed by logistic regression,and the diagnostic value of IL-33 was analyzed by ROC curve Results 1)The difference in the serum IL-33 levels among the 4 groups was statistically significant(P＜0.05).Compared with the HC group,the IL-33 levels were lower in the AD and MCI groups,and the difference was statistically significant(P＜0.05);compared with the SCD group,the IL-33 levels were lower in the AD and MCI groups,and the difference was statistically significant(P＜0.05);compared with the MCI group,the IL-33 level was lower in the AD group,and the difference was statistically significant(P＜0.05);the difference of the IL-33 levels in the SCD and HC groups was not statistically significant(P＞0.05).2)The serum IL-33 levels were positively correlated with MMSE(r=0.578,P＜0.001)and MoCA(r=0.583,P＜0.001).3)Multivariate logistic regression analysis suggested that education level(OR=0.385,P＜0.05),homocysteine(OR=1.142,P＜0.05),IL-33(OR=0.902,P＜0.05)were the risk factors for the occurrence of AD;the area under the curve of serum IL-33 for the diagnosis of AD was 0.865(95%CI 0.786-0.943),with a sensitivity of 87.0%,a specificity of 80.0%,and a CUT-off of 49.135(P＜0.05);the area under the curve of combined education level,serum homocysteine level and serum IL-33 level for the diagnosis of AD was 0.894(95%CI 0.825-0.962),with a sensitivity of 89.1%and a specificity of 83.7%(P＜0.05).Conclusion 1)In this study,the expression level of serum IL-33 was different in the 4 groups,the lowest in the AD group and the highest in the HC group.There was no statistically significant difference between IL-33 and SCD risk.2)the serum IL-33 expression level was positively correlated with cognitive function.3)Serum IL-33 may be an independent protective factor for the development of AD.It may be a biomarker for the auxiliary diagnosis of AD and provide new ideas for the early diagnosis and treatment of AD.4)Education level,serum IL-33 level and serum homocysteine level are all risk factors in the development of AD,and the combination of multiple factors is more effective in the diagnosis of AD.
Alzheimer's diseasemild cognitive impairmentsubjective cognitive declineinterleukin-33cognitive function
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