三价砷致肾损伤的中西医防治研究进展
Chinese and Western Medicine Studies on the Prevention and Treatment of Renal Injury Caused by Trivalent Arsenic:a Systematic Review
宋智勇 1龚学忠1
作者信息
- 1. 上海中医药大学附属市中医医院肾内科,上海 200071
- 折叠
摘要
三价砷(AS Ⅲ)在临床上常用于治疗急性早幼粒细胞白血病(APL),疗效较为显著,但其自身毒性限制了临床应用范围.AS Ⅲ的主要排泄器官是肾脏,其肾毒性常导致肾脏结构和功能的严重受损.目前,AS Ⅲ致肾损伤的具体机制尚未完全阐明,且缺乏有效的预防和治疗手段.文章综述了AS Ⅲ致肾损伤的发病率和风险、致病机制和防治手段方面的研究进展.
Abstract
Trivalent arsenic(ASⅢ)is commonly used in the management of acute promyelocytic leukemia(APL),with positive therapeutic outcomes,but its autotoxicity limits its clinical application.Serving as the main excretory organ for ASⅢ,the kidney is particularly susceptible to its nephrotoxic effects,which can result in significant structural and functional impairments.Nevertheless,the pathogenesis of kidney injury caused by ASⅢ has not been fully elucidated,and effective preventive and therapeutic strategies are lacking.This article provides a comprehensive review of research advances in the incidence and risk of the pathogenesis,prevention and treatment of nephrotoxicity associated with arsenic-induced renal injury.
关键词
三价砷/肾损伤/发病机制/中西医防治Key words
trivalent arsenic/kidney injury/pathogenesis/prevention and treatment of Chinese and western medicine引用本文复制引用
基金项目
国家自然科学基金面上项目(82074387)
国家自然科学基金面上项目(81873280)
出版年
2024
NETL
NSTL
万方数据