Salivary Gland Ultrasonic Scoring Combined with Shear-wave Elastography in the Diagnosis of Primary Sjogren's Syndrome
Objective To investigate application value of salivary gland ultrasound scoring combined with shear-wave elastography(SWE)in the diagnosis of primary Sjogren's syndrome(pSS).Methods 106 patients with suspected pSS with dry eyes and dry mouth,admitted to the First Affiliated Hospital of Nanchang University from December 2020 to December 2021,were prospectively selected.Based on diagnostic results,they were divided into a pSS group(confirmed pSS,n=62)and a non-pSS group(pSS excluded,n=44).All patients underwent bilateral parotid gland and bilateral submandibular gland two-dimensional ultrasonography and SWE examination.Ultrasonic scoring and SWE Young's modulus value measurement were performed.The efficacy of ultrasound scoring alone,SWE,and ultrasound scoring combined with SWE for the diagnosis of pSS in the parotid and submandibular glands was compared by plotting ROC curves.Results The ultrasound scores of parotid and submandibular glands in the pSS group were higher than those in the non-pSS group(both P＜0.001).The Young's modulus values of parotid and submandibular glands in the pSS group were significantly higher than those in the non-pSS group(both P＜0.01).There was no significant difference in AUC between the parotid ultrasound scoring diagnosis and the SWE diagnosis(P=0.093).The AUC of the combined diagnosis was significantly higher than that of the ultrasound scoring diagnosis(P=0.002),while there was no significant difference in AUC between the SWE diagnosis and the combined diagnosis(P=0.072).The AUC of the submandibular gland ultrasound scoring diagnosis was significantly higher than that of the SWE diagnosis(P=0.028).There was no significant difference in AUC between the ultrasound scoring diagnosis and the combined diagnosis(P=0.349),while the AUC of the combined diagnosis was significantly higher than that of the SWE diagnosis(P＜0.001).Conclusions The ultrasound scoring method demonstrates positive diagnostic efficacy for pSS in both parotid and submandibular glands.SWE is more valuable for the evaluation of parotid gland involvement than the submandibular gland in pSS patients,and the addition of SWE in the ultrasound scoring can improve the specificity of diagnosis.When performing ultrasound examination on early-stage patients with suspected pSS symptoms such as dry mouth and eyes,priority should be given to parotid gland examination.
万方数据
维普
