Acute Leukemia Complicated with Tropical Candida Osteomyelitis:a Case Report and Literature Review
Objective To analyze a case of acute leukemia complicated with severe disseminated tropical candidemia and multiple organ invasion after chemotherapy so as to accumulate clinical experience for invasive fungal infections.Methods Relevant domestic and international literature was reviewed,and a retrospective analysis was conducted of clinical diagnosis and treatment of a patient with invasive fungal disease after leukemia chemotherapy.Results The patient,a 59-year-old male diagnosed with acute myeloid leukemia,developed severe myelosuppression and disseminated tropical candidemia after receiving multiple high-dose cytarabine chemotherapy,resulting in rib osteomyelitis,costochondritis,and chest wall abscess.The patient's condition stabilized after undergoing focal debridement combined with amphotericin B,caspofungin,and fluorouracil treatment.Conclusion Disseminated tropical candidemia during the myelosuppression phase after chemotherapy can lead to costochondritis and further invasion of surrounding tissues,and it is necessary to differentiate this condition from bone tuberculosis and extramedullary infiltration of leukemia;simultaneously,a combination of surgical intervention and adequate antifungal therapy is required to achieve an effective therapeutic effect.
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