Exploring the Mechanism of Dredging the Liver and Removing Blood Stasis Method Based on HPG/HPA Axis of Treating Melasma with Liver Stagnation and Blood Stasis
Objective:To observe the effect of treatment with Modified Taohong Siwu Decoction combined with Zhenzhu Wubai Facial Mask on the HPG/HPA axis of melasma patients with liver depression and blood stasis,and to explore the mechanism of dredging the Liver and removing blood stasis method in the treatment of melasma.Methods:Ninety patients with melasma caused by liver depression and blood stasis were randomly divided into three groups:the basic treatment group was treated with oral supplementation of Modified Taohong Siwu Decoction,the control group was treated with external use of hydroquinone cream on the basic treatment group,and the observation group was treated with external use of Zhenzhu Wubai Facial Mask on the basic treatment group for 8 weeks.Results:The LH,E2,FSH,MSH and CORT decreased in the three groups after treatment(P<0.05),and the improvement in the observation group was significant compared with the basic treatment group and the control group(P<0.05).Conclusion:The combination therapy of Modified Taohong Siwu Decoction and Zhenzhu Wubai Facial Mask can significantly decrease the LH,E2,FSH,MSH and CORT level in patients with melasma with liver stagnation and blood stasis,suggesting that the mechanism of treating melasma with the method of dredging the liver and removing blood stasis achieved by regulating the changes of HPG axis and HPA axis.
ChloasmaLiver Depression and Blood StasisZhenzhu Wubai PowderHPG AxisHPA Axis