Objective:To observe the effect of Purpura No.1 Prescription on the expression of eosinophils and Fas protein in peripheral blood of children with Henoch-Schonein Purpura Nephritis(HSPN).Methods:Children with HSPN who visited the outpatient and/or inpatient department of Shenzhen Traditional Chinese Medicine Hospital from October 1st,2019 to December 30th,2020 were randomly divided into observation group(n=30)and control group(n=30).The observation group was treated with Purpura kidney No.1 prescription and traditional Chinese medicine injection,while the control group was treated with common western medicine.The treatment course of both groups was 12 weeks.The changes of urine N-acetylglucosaminidase(NAG),urine microalbumin(mALB),β2-microglobulin(β2-MG),blood eosinophile granulocyte(EOS)and factor asscioated suicide(Fas)and the changes of curative effect were observed before treatment,at the 0th,4th,8th and 12th weeks of treatment.Results:The effective rate of Henoch-Schonlein Purpura No.1 prescription at the 4th and 8th weeks were 83.33%and 96.67%,which was higher than that of the control group(P<0.05).At the 4th and 8th weeks,the observation group was superior to the control group in reducing NAG,and the difference was statistically significant(P<0.01).The reduction of β2-MG in the treatment group was better than that in the control group at each observation time point,and the difference was statistically significant(P<0.05).At the 4th and 12th week,the decrease of mALB in the observation group was better than that in the control group,and the difference was statistically significant(P<0.05).At the 4th week,the control group was superior to the treatment group in promoting Fas antigen expression and reducing EOS,and the difference was statistically significant(P<0.01).Conclusion:Henoch-Schonlein Purpura No.1 prescription can improve the clinical symptoms of children with HSPN in the early stage,and has a faster and more lasting effect on improving early renal damage indexes.
Henoch-Schonein Purpura NephritisPurpura No.1 PrescriptionChildrenChinese Medicine Injection
维普
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