Study on the Screening of Hypolipidemic Active Fractions from Coreopsis Tinctoria Nutt.
Objective:To determine the lipid-lowering active site of Coreopsis tinctoria Nutt.Methods:The solvent method was used to screen the optimal extraction solvent for lipid-lowering activity,and the extract was refined and purified for lipid-lowering activity evaluation.Results:The aqueous extract of Coreopsis tinctoria Nutt.can significantly reduce the levels of TC and LDL-C in the serum of hyperlipidemic mice at high doses.The refined fraction of water extract can significantly reduce serum TC and LDL-C content at low doses.Both water extract and the 30%ethanol elution site through macroporous adsorption resin can significantly reduce serum TC and LDL-C content at high doses.Conclusion:The optimal extraction solvent for the two color Chrysanthemum is water,and the 30%ethanol elution site of the macroporous adsorption resin is the active site.
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