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电针对膝骨关节炎软骨细胞的作用机制研究进展

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膝骨关节炎是我国常见的中老年慢性骨关节疾病之一,目前治疗方法有很多,其中电针疗法临床运用广泛.研究证实,电针可通过调节软骨细胞的增殖、分化、凋亡过程及抑制软骨基质降解治疗膝骨关节炎,但其具体作用机制仍未阐明.近年国内外文献表明,膝关节软骨细胞的生成、增殖凋亡过程与相关炎症因子、信号通路、线粒体及蛋白、生物力学等密切相关,现从以上四方面综述电针对膝骨关节炎软骨细胞的作用机制,为今后更深入的研究提供参考.
Research Progress on the Mechanism of Electroacupuncture on Chondrocytes in Knee Osteoarthritis
Knee osteoarthritis is one of the common chronic joint diseases in middle-aged and elderly people in China.There are many treatment methods,among which electroacupuncture is widely used in clinic.Electroacupuncture can treat knee osteoarthritis by regulating the proliferation,differentiation and apoptosis of chondrocytes and inhibiting the degradation of cartilage matrix,but its specific mechanism has not been elucidated.In recent years,domestic and foreign literatures have shown that the formation,proliferation and apoptosis of knee articular chondrocytes are closely related to related inflammatory factors,signaling pathways,biomechanics,mitochondria and proteins.This paper reviews the mechanism of electroacupuncture on knee osteoarthritis chondrocytes in the above four aspects,so as to provide reference for further research in the future.

ElectroacupunctureKnee OsteoarthritisChondrocytesMechanism of ActionReview

王嘉璐、熊昌源、陈建锋、陈洪波

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湖北中医药大学针灸骨伤学院 武汉 430061

湖北省中医院 武汉 430060

电针 膝骨关节炎 软骨细胞 作用机制 综述

国家中医药管理局全国名老中医药专家熊昌源传承工作室建设项目

国中医药人教函[2022]75号

2024

江西中医药大学学报
江西中医学院

江西中医药大学学报

影响因子:0.575
ISSN:2095-7785
年,卷(期):2024.36(4)