江西中医药大学学报2024,Vol.36Issue(4) :114-117,122.DOI:10.20140/j.2095-7785.2024.04.26

电针对膝骨关节炎软骨细胞的作用机制研究进展

Research Progress on the Mechanism of Electroacupuncture on Chondrocytes in Knee Osteoarthritis

王嘉璐 熊昌源 陈建锋 陈洪波
江西中医药大学学报2024,Vol.36Issue(4) :114-117,122.DOI:10.20140/j.2095-7785.2024.04.26

电针对膝骨关节炎软骨细胞的作用机制研究进展

Research Progress on the Mechanism of Electroacupuncture on Chondrocytes in Knee Osteoarthritis

王嘉璐 1熊昌源 2陈建锋 2陈洪波1
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作者信息

  • 1. 湖北中医药大学针灸骨伤学院 武汉 430061
  • 2. 湖北省中医院 武汉 430060
  • 折叠

摘要

膝骨关节炎是我国常见的中老年慢性骨关节疾病之一,目前治疗方法有很多,其中电针疗法临床运用广泛.研究证实,电针可通过调节软骨细胞的增殖、分化、凋亡过程及抑制软骨基质降解治疗膝骨关节炎,但其具体作用机制仍未阐明.近年国内外文献表明,膝关节软骨细胞的生成、增殖凋亡过程与相关炎症因子、信号通路、线粒体及蛋白、生物力学等密切相关,现从以上四方面综述电针对膝骨关节炎软骨细胞的作用机制,为今后更深入的研究提供参考.

Abstract

Knee osteoarthritis is one of the common chronic joint diseases in middle-aged and elderly people in China.There are many treatment methods,among which electroacupuncture is widely used in clinic.Electroacupuncture can treat knee osteoarthritis by regulating the proliferation,differentiation and apoptosis of chondrocytes and inhibiting the degradation of cartilage matrix,but its specific mechanism has not been elucidated.In recent years,domestic and foreign literatures have shown that the formation,proliferation and apoptosis of knee articular chondrocytes are closely related to related inflammatory factors,signaling pathways,biomechanics,mitochondria and proteins.This paper reviews the mechanism of electroacupuncture on knee osteoarthritis chondrocytes in the above four aspects,so as to provide reference for further research in the future.

关键词

电针/膝骨关节炎/软骨细胞/作用机制/综述

Key words

Electroacupuncture/Knee Osteoarthritis/Chondrocytes/Mechanism of Action/Review

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基金项目

国家中医药管理局全国名老中医药专家熊昌源传承工作室建设项目(国中医药人教函[2022]75号)

出版年

2024
江西中医药大学学报
江西中医学院

江西中医药大学学报

影响因子:0.575
ISSN:2095-7785
参考文献量44
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